The Interaction of Dietary Pectin, Inulin, and Psyllium with Copper Nanoparticle Induced Changes to the Cardiovascular System

We aimed to analyze how supplementation with a standard (recommended, 6.5 mg/kg) or enhanced (two-times higher, 13 dose of copper (Cu), in the form nanoparticles (NPs) along dietary intervention via implementation diverse types fiber, affects cardiovascular system rats. Nine-week-old male Wistar Han rats (n/group = 10) received, for an additional 6 weeks, controlled diet cellulose as fiber and ionic Cu (in carbonate salt). The experimental groups received cellulose, pectin, inulin, psyllium together CuNPs (6.5 mg/kg diet). After feeding, samples blood, hearts, thoracic arteries were collected further analysis. Compared under CuNPs, inulin beneficially increased antioxidant capacity lipid- water-soluble compounds decreased heart malondialdehyde. Moreover, pectin catalase (CAT) cyclooxygenase (COX)-2 aortic rings compared doses copper. When was enhanced, potentiated vasodilation acetylcholine by up-regulation COX-2-derived vasodilator prostanoids both this modulated selective inducible nitric oxide synthase (iNOS) inhibitor only. CAT psyllium. Our results suggest that may protect vascular against potentially harmful metal NPs modulating mechanisms.